"Dean didn't want Cas to save him." Chuck
Dean: "You really suck at goodbyes, you know that?"
Cas: "You're hurt."
"Are you angry? Why are you angry?" Cas to Dean
"Cas is our family. So we can't let you hurt him!" Dean
"Dean, we'll get him back." Sam about Cas
"Don't worry, we'll bring him back." Sam to Cas about Dean
Sam to Cas: "Where have you been?"
Dean: "Let me rephrase that. Where the hell have you been?!"
Sam: "Thanks for coming, Cas."
Cas: "Of course. Where's Dean?"
"Remember me? I sure remember you, Clarence."
"That was beautiful, Clarence."
"Why are you so sweet on me, Clarence?"
"We're going to heaven, Clarence."
When Meg calls Castiel Clarence, she is referring to the film 'It's a Wonderful Life' from 1946, in which the angel Clarence shows the human George Balley that his life is worth living.
"I dragged you out of hell. I can throw you back in." Cas to Dean
Girl: "Why does Dean call Jack half-angel in the last episode but antichrist and other bad names before?"
Jensen: "In the beginning, he could only see Lucifer in Jack, now he sees Cas."
"It may be unspoken but that doesn't mean it's not there." Misha Collins
"Dean didn't act on his feelings for Cas because he thought Cas couldn't feel human emotions." Jensen Ackles
"I've never believed that beauty could exist in selfdestruction. Then I saw you. And your eyes told stories with dangerous beginnings and lost endings, where every page was breathing with color. Yes, you were beautiful to me." - Nicole Torres